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pentobarbital will lower the level or effect of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some decrease in fentanyl plasma concentrations, deficiency of efficacy or, possibly, growth of a withdrawal syndrome within a

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